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Ciba Foundation Symposium 149 - Human Genetic Information: - download pdf or read online

ISBN-10: 047051390X

ISBN-13: 9780470513903

ISBN-10: 0471926248

ISBN-13: 9780471926245

As a part of a continuous attempt to take on problems with significant social difficulty, this 280th convention of across the world famous specialists from the fields of molecular biology, drugs, philosophy, theology, and the legislations seems into the medical, felony, moral, social, and monetary matters confronting guy and his skill to map and series the human genome. a large choice of matters are coated, together with prenatal prognosis, advances within the genetics of psychiatric problems, the issues linked to polygenic sickness, and the bounds to genetic intervention in people. The symposium additionally discusses genetic manipulation, advertisement exploitation, and criminal implications.


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Extra info for Ciba Foundation Symposium 149 - Human Genetic Information: Science, Law and Ethics

Example text

The DNA profile obtained by use of an SLP provides just two bands to analyse, one each from the two chromosomal copies of that DNA region (Wong et al 1986, 1987). Some SLPs have more than 100 detectable alleles and each allele is of relatively low frequency in the population. Thus the succesive application of a series of SLP tests to a forensic DNA sample can build up a near-unique identification. The principal attraction of SLPs is their greatly increased sensitivity, such that it is possible to obtain a DNA profile from a single hair root.

Classical molecular biology techniques had been used to delineate the map of this region using pulsed-field gel electrophoresis (Hardy et a1 1986) and to characterize the sequence variation of most of the major alleles in the region, using allelic nucleic acid sequencing of products derived using the polymerase chain reaction (Bell et a1 1987). Analysis of these gene sequences in populations of patients revealed correlations between certain structural determinants and susceptibility, or lack of susceptibility, to insulin-dependent diabetes, and susceptibility to rheumatoid arthritis (Todd et a1 1988).

There is a dilemma in the USA because one of the political forces that enhanced the human genome programme is economic competitiveness. This means that the programme may have a chauvinistic tendency built into it, and this may affect international aspects of the project. Neverthless, it is likely that major scientific resources will go into the study of the human genome in America. Of course, there are now many organizations, including the Ciba Foundation, who are interested in the moral, ethical, legal and organizational aspects: there is a meeting on the mctagenetics of the human genome every month.

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Ciba Foundation Symposium 149 - Human Genetic Information: Science, Law and Ethics

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