By D. Schulte-Frohlinde (auth.), Professor Dr. Günter Obe, Professor Dr. Adayapalam T. Natarajan (eds.)
Due to delicate molecular organic options, our figuring out of chromosomal aberrations is progressively expanding. supplied here's a assessment of uncomplicated and utilized elements of the sector. Chromosome constitution, induction of DNA lesions through various clastogenic brokers and their fix, induction of aberrations via brokers which have an effect on particular sequences within the DNA, and components affecting induction and yield of chromosomal aberrations are coated.
Further, issues equivalent to automation of aberration scoring, difficulties linked to utilizing chromosomal aberrations and micronuclei in inhabitants tracking and the significance of chromosomal aberration assays in mutagenicity checking out of chemical compounds are included.
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Extra info for Chromosomal Alterations: Origin and Significance
Nature 298: 679-681 Dauwerse JG, Wiegant J, Raap AK, Breuning MH, van Ommen GJB (1992) Multiple colors by fluorescence in situ hybridization using ratio-labelled DNA probes create a molecular karyotype. Hum Mol Genet. 1: 593-598. du Manoir S, Speicher MR, Joos S, Schrock E, Popp S, Dohner H, Kovacs G, Robert-Nicoud M, Lichter P, Cremer T (1993) Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet. In Press Joos S, Scherthan H, Speicher MR, Schlegel J, Cremer T, Lichter P (1993) Detection of amplified DNA sequences by reserve chromosome painting using genomic tumor DNA as probe.
5 for pentasomies, and so forth. , 1993). The optimal exposure time for each slide and filter set was chosen in order to avoid saturation values in all pixels, and to cOver at least half total dynamic range of the camera. Exposure times and all optical settings of the microscope were kept constant for a whole series of image acquisitions. Identification of chromosomes was made on the basis of DAPI CCDimages. , Grenoble, France) or the TCL Image software (Multihouse, Amsterdam, The Netherlands).
T. Sakamoto Hojo, H. J. Dh and F. Darroudi. MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Wassenaarseweg 72, AL 2333, Leiden, The Netherlands and J. A. Cohen Institute, Inter University Institute for Radiation Protection & Radiopathology, Leiden, The Netherlands 1 Introduction Fluorescent in situ hybridization (FISH) using non-radioactive probes has become an important tool in cytogenetics. With this technique, using chromosome specific DNA libraries, one can paint whole chromosomes, or using specific probes it is possible to hybridize with specific regions of the chromosome, such as telomeres, centromeres etc.
Chromosomal Alterations: Origin and Significance by D. Schulte-Frohlinde (auth.), Professor Dr. Günter Obe, Professor Dr. Adayapalam T. Natarajan (eds.)