By Douglas P. Zipes MD, Jose Jalife MD
Cardiac Electrophysiology: From phone to Bedside defines the whole country of present clinical and scientific wisdom during this subspecialty. in accordance with the various significant contemporary advancements within the box, Drs. Zipes and Jalife have thoroughly up to date this contemporary vintage, making the fifth variation the main major revision but. From our most modern realizing of ion channels, molecular genetics, and cardiac electric task via newly well-known syndromes, detailed wishes of distinct sufferer populations, and new diagnostic and healing techniques, you can find all of the state of the art tips you must make proficient, potent scientific judgements. what is extra, a considerably restructured association, a brand new full-color format, and full-text on-line entry make reference more straightforward than ever.Integrates the newest clinical figuring out of arrhythmias with the most recent scientific purposes, providing you with an educated foundation for selecting definitely the right therapy and administration innovations for every patient.Synthesizes the information of preeminent experts in cardiology, body structure, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgical procedure, and biomedical engineering from world wide, supplying you with a well-rounded, specialist clutch of each factor that has effects on your sufferer management.Contains 24 new chapters (listed less than) in addition to exhaustive updates all through, to maintain you present with new medical wisdom, newly stumbled on arrhythmia syndromes, and new diagnostic and healing techniques.Developmental law of Cardiac Ion ChannelsNeural Mechanisms of starting up and protecting ArrhythmiasSingle Nucleotide Polymorphisms and purchased Cardiac ArrhythmiasInheritable Sodium Channel DiseasesInheritable Potassium Channel DiseasesInheritable ailments of Intracellular Calcium RegulationMorphological Correlates of Atrial ArrhythmiasAndersen-Tawil SyndromeTimothy SyndromeProgressive Cardiac Conduction DiseaseSudden child dying SyndromeArrhythmias in sufferers with Neurologic DisordersAutonomic TestingCardiac Resynchronization TherapyEnergy assets for Catheter AblationLinear Lesions to Ablate Atrial FibrillationCatheter Ablation of Ventricular Arrhythmias in sufferers with Structural middle DiseaseCatheter Ablation of Ventricular Arrhythmias in sufferers with no Structural middle DiseaseCatheter Ablation in sufferers with Congenital middle DiseaseFeatures a very new part on "Arrhythmias in certain Populations" that explores arrhythmias in athletes ... gender adjustments in arrhythmias ... arrhythmias in pediatric sufferers ... and sleep-disordered respiring and arrhythmias.Offers an enticing new full-color layout that includes colour images, tables, circulation charts, ECGs, and extra, making clinically actionable details effortless to discover and take up at a glance.Includes full-text on-line entry through professional seek advice, making reference more uncomplicated for busy practitioners.Your buy entitles you to entry the website till the following version is released, or until eventually the present variation is not any longer provided on the market by means of Elsevier, whichever happens first. If the following variation is released lower than 365 days after your buy, you can be entitled to on-line entry for three hundred and sixty five days out of your date of buy. Elsevier reserves the proper to supply an appropriate substitute product (such as a downloadable or CD-ROM-based digital model) should still on-line entry to the website be discontinued.
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Additional resources for Cardiac Electrophysiology: From Cell to Bedside: Expert Consult - Online and Print, Fifth Edition
Thus, the channel protein senses a more negative voltage, and a greater depolarization will be required for the channel to reach the threshold for activation. This effect applies to all Em-dependent channels and applies equally to the Em dependence of inactivation. It explains the increased excitability of cells in low calcium concentrations. Conversely, high extracellular Ca2+ concentration stabilizes Em-dependent channels and reduces excitability (a rightward shift of the curves in Fig. 2-6A).
Schlief T, Scho¨nherr R, Imoto K, Heinemann SH: Pore properties of rat brain II sodium channels mutated in the selectivity filter domain. Eur Biophys J 25:75-91, 1996. Sun YM, Favre I, Schild L, Moczydlowski E: On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel—effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving. J Gen Physiol 110:693715, 1997. Miller C: Annus mirabilis for potassium channels.
90. 91. 92. 93. 94. 17 transmembrane segment IIIS6 of the Na channel a subunit. J Biol Chem 276:20-27, 2001. Yarov-Yarovoy V, McPhee JC, Idsvoog D, et al: Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel a subunit in voltage-dependent gating and drug block. J Biol Chem 277:35393-35401, 2002. Hille B: Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69:497-515, 1977. Hondeghem LM, Katzung BG: Antiarrhythmic agents: The modulated receptor mechanism of action of sodium and calcium channel-blocking drugs.
Cardiac Electrophysiology: From Cell to Bedside: Expert Consult - Online and Print, Fifth Edition by Douglas P. Zipes MD, Jose Jalife MD