By Ana Lucia Abujamra
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Extra resources for Brain Tumors - Current and Emerging Therapeutic Strategies
38 Brain Tumors - Current and Emerging Therapeutic Strategies 5-methylcytosine (m5C), along with other DNA constituents and the cell components, are targets for ROS, of which the most reactive species is the hydroxyl radical (•OH). Hydroxyl radical causes a wide range of DNA lesions including base modifications, deletions and strands breakage. Radical oxidation of m5C leads to its modification including demethylation and deamination (Fig. 1). It results in decreasing the global (genomic) m5C content in cellular DNA (hypomethylation).
The murine glioma RN-2 derived from the induction by ethyl-nitrosourea in F344 rats. It transplanted well and has a stable glial population, many expressing antigenic markers. These and other models are commonly used in experimental neuro-oncology, but it is essential to know the limitations of each of the experimental brain tumor models, and depending upon the nature of the study to be conducted, it is important that the appropiate model be selected (Barth and Kaur, 2009). In any case, the achievement of stable tumor cell lines, capable of growing in immunocompetent animals, is of great importance to study the efficacy of new antitumor drugs or biological agents capable of modifying the biological response in presence of a brain tumor.
One can clearly see that the global DNA methylation analysis easily differentiate low and high grade tumours as well as metastatic (Fig. 7). Different relations occur for meningeomas (Fig. 8, Table 2). Table 1. The list of human brain tumours of neuroepithelial origin (total number 297) identified in patients. For each of them malignancy and m5C content [R] were established. 46 Brain Tumors - Current and Emerging Therapeutic Strategies Fig. 6. 0003) of global DNA (m5C) methylation expressed as R for different human gliomas with different malignancy grades (I-IV).
Brain Tumors - Current and Emerging Therapeutic Strategies by Ana Lucia Abujamra